Protein engineering: Redirecting membrane machinery

edited August 2017 in Biology

Burley, K. & Goulding, C. W. Protein engineering: Redirecting membrane machinery. Nature Chemical Biology 13, 927–928 (2017).
https://www.nature.com/nchembio/journal/v13/n9/full/nchembio.2451.html
Abstract: The ability to solubilize membrane proteins while retaining their native function is a persistent challenge. Re-engineering of the membrane protein DsbB into a soluble cytoplasmic version maintained its activity and enabled recompartmentalization of the periplasmic DsbAB disulfide bond–forming system.

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